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Going Global 한스쉘러줄기세포연구센터

Molecular Biomedicine Lab.

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Welcome to the Molecular Biomedicine Laboratory.

 
The paradigm of regenerative medicine was thoroughly changed when induced pluripotent stem cells (iPS) were first derived by Shinaya Yamanaka. Importantly, iPS can be used as a source for patient-specific cell therapies. In addition, the ethical concerns and the limitations associated with embryonic stem cell (ESC), namely immune rejection, could also be overcome.
Direct conversion is another innovative technique. Because it doesn’t need iPS intermediate state to make patients specific stem cells, it can rule out the possibility of tumorigenecity .
 
Our research is based on an understanding of the mechanism of iPS reprogramming, direct conversion and the generation of patient-specific stem cells for future cell therapy. The aim is to develop innovative cell therapeutic methods for clinical applications and possible solutions for degenerative and currently incurable disease. In addition, iPS cells and direct conversion can also be used for innovative techniques of drug screening and toxicity tests. Therefore, the therapeutic potential of iPS cell and direct converted cells are very promising.
 
 
Moreover, we are collaborating with the Max Planck Institute for Molecular Biomedicine (MPI-MBM) located in Muenster, Germany. This collaboration will creat synergic effects that will be mutually beneficial. Continuously seeking new areas of collaboration, we will reach out to become a world-class stem cell research group.
 
 

 

PI

 

.김정범(Jeong Beom Kim) 

http://hsscrc.unist.ac.kr/userfiles/images/jbkim.jpg - School : Nano-Bioscience and Chemical Engineering, UNIST

 - Title : Assistant Professor

 - Address : 689-798 100 Banyeon-ri, Eonyang-eup, Ulju-gun, Ulsan

 - Phone : 052)217-2524

 - Fax : 052)217-2639

 - E-mail : jbkim@unist.ac.kr

 

 

 

 

 

 

 

 

 

 

 

Lab Members

>> Senior researcher

Lee, Taehee

Eucation

Ph.D., Applied Biology, Dongguk University, Seoul, Korea, 2001 to 2005
M.S., Applied Biology, Dongguk University, Seoul, Korea, 1999 to 2001

Professional Experience
Ulsan National Institute of Science and Technology
Senior Researcher
Hans Schöler Stem Cell Research Center                       Oct 2015~  

Georgetown University Medical Center, Washington, DC, USA
Research Associate,
Neuroscience                                                          Feb 2012~Jun 2013
 
Pennsylvania State University College of Medicine, Hershey, USA
Post-Doctoral Fellow,
Neurosurgery & Neuroscience Institute                         Mar 2009~Dec 2011
 
Sun Health Research Institute, Sun City, USA
Post-Doctoral Fellow,
Haldeman Lab. of Molecular & Cellular Neurobiology       Feb 2007~Mar 2008
 
Dongguk University Gyeongju Campus, Gyeongju, Korea                                       
Full-time Instructor, Life Science                                       Sep 2002~Dec 2006
Research Professor, Life Science and Technology Institute      Sep 2005~Dec 2006
 
 
Research interest
  • APP signaling pathways and the mechanism by novel small molecule affect Alzheimer’s disease (AD)
  • Expression of G protein-coupled receptors in brains with AD
  • Synapse formation
  • Corticofugal projection
* contact : thlee525@hotmail.com


Lee, Sang Min

Education 

Ph.D., Gyeongsang National University, Korea 

Professional Experience
 
12/2015 – present 
Ulsan National Institute of Science and Technology
Senior Researcher
Hans Schöler Stem Cell Research Center                        
 
07/2014 - 12/2015
University of Connecticut, USA
Post-doc Fellow (Metabolic diseases)
 
07/2012 – 06/2014 
University of Utah School of Medicine, USA
Post-doc Fellow (alcoholic liver diseases)
 
06/2012 – 06/2011 
Ulsan National Institute of Science and Technology
Post-doc Fellow (Calcium signaling)
 
 
Research Interest
 
Stem Cell Metabolism
Direct Reprogramming; Drug screening




>>Postdoctoral fellow

이석진
 
Seok-Jin Lee
 
Education
Ph.D., Duke University (08/2007 - 02/2011)
B.S., Duke University (08/2003 - 05/2007)
 
Motto
"There is no comfortable route for a scientist. You want to learn to get comfortable with being uncomfortable."
- Elaine Fuchs
 
Research Interest
Biology of neural stem cells and its therapeutic potential

* contact : sjlee8@unist.ac.kr

 

>> PH.D candidates

 

Myung Rae Park (박명래)

 

Education
M.S.,KonKuk University, 2008 to 2010 
B.S.,Keimyung University, 2001 to 2007 

                                                                                                                                                                                                     

Motto

"'Trial & error' is a ladder that reaching for the truth."

Research Interest

Direct reprogramming; Drug screening.

 

* contact : rae3208@unist.ac.kr

 

 

 

>> Combined MS-doctoral course

 

 
 
 
 
 
 
 
 
 
Hyun Ah Lee (이현아)
 
Education
B.S., University of Ulsan, 2007 to 2011.
 
Motto
"Wheresover you go, go with all your heart."
 
Research Interest
iPS cells; Direct reprogramming.
 
* contact : hyuna1000je@nate.com
 
 

 

   
Soo Yong Park (박수용)
 
Education
B.S., Kyungpook National University, 2005 to 2012
 
Motto
"Do my best in everything."
 
Research Interest
Direct reprogramming, patient-specific stem cell
 
* contact : shorypark@naver.com
 
 
 




Ji Hye Park(박지혜)
 


Education
B.S., Ulsan National Institute of Science and Technology, 2010 ~ 2014

Motto
Where there is a will there is a way.
 

Research Interest
Direct conversion, Cancer Stem cells, Gene editing
 
* contact : jihyepark1019@gmail.com

 

 
Ji Hoon Son(손지훈)
 

Education
B.S., Ulsan National Institute of Science and Technology, 2012 -

 

Motto
"You can because you think you can"

 

Research Interest
iPS cells, Direct reprogramming

 

* contact : thswlgns203@unist.ac.kr




Hong dae Seo(서홍대)


Education
B.S., Ulsan National Institute of Science and Technology, 2010 -


Motto
"Life is timing"


Research Interest
iPS cells, Direct conversion


* contact : ha980121@naver.com

>> Master course





Donggyu Nam(남동규)
Education
Honours in B.S., University of Toronto, St. George campus, 2006 to 2014
 
Motto
Just do it.
 
Research interest
Gene editing, Direct reprogramming/iPS cells
 
* contact : mymy301@gmail.com
 



Ju-Chan Lim(임주찬)
 
Education
B.S., Yeungnam University, Kyungsan campus, 2009 to 2015
 
Motto
The fear of the Lord is the beginning of knowledge.(Prov 1:7)
 
Research interest
Spinal cord regeneration, Organogenesis
 
*Contact : Juchanlim91@gmail.com
 



Yujin Jeong(정유진)
Education
B.S., Incheon national university , 2011 ~ 2014
 
Motto
If you don’t walk today, you have to run tomorrow.
 
Research interest
Gene editing, Direct reprogramming, iPS cells
 
* contact : jyj10142001@gmail.com



>> Undergraduates
 


>> Alumni





WONG Man Sze(Mancy)

Education
M.S., Ulsan National Institute of Science and Technology 2012-2015
B.S., The Hong Kong University of Science and Technology 2009-2012
 

Motto

"Nothing more nothing less, just enough"
 

Research Interest

iPS cells, direct reprogramming

 

* contact : mancycat1@gmail.com


 
 


Kim SM, Lim KT, Kwak TH, Lee SC, Im JH, Hali S, In Hwang S, Kim D, Hwang J, Kim KP, Chung HJ, Kim JB, Ko K, Chung HM, Lee HT, Schöler HR, Han DW 
Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status. Stem Cells Res.  2016 Feb 10; 16(2): 460 - 468

Hyunah Lee, Donggyu Nam, Jae-Kyung Choi, Marcos J. Araúzo-Bravo, Soon-Yong Kwon, Holm Zaehres, Taehee Lee, Chan Young Park, Hyun-Wook Kang, Hans R. Schöler & Jeong Beom Kim
Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene. Scientific reports. 2016 Feb; 6(1): 1 - 11

Andreas Hermann, Jeong Beom Kim, Sumitra Srimasorn, Holm Zaehres, Peter Reinhardt, Hans R. Schöler, and Alexander Storch
Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors. Stem Cells International. 2016 Feb; 2016(1): 1 - 6

Jeong Beom Kim, Hyunah Lee, Marcos J Araúzo-Bravo, Kyujin Hwang, Donggyu Nam, Myung Rae Park, Holm Zaehres, Kook In Park, Seok-Jin Lee
Oct4-induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model. EMBO journal. 2015 Oct; 34(20): 2483 - 2596

Se-Yang Kim, Jinsung Kwak, Jae Hwan Chu, Jeong Beom Kim, Sung Youb Kim, Kibog Park , and Soon-Yong Kwon
Controllable Synthesis of Graphene Encapsulated Low-Dimensional Nanocomposites. Advanced materials interfaces. 2015 Jun;2(11):1-7

Dorn I, Klich K, Arauzo-Bravo MJ, Radstaak M, Santourlidis S, Ghanjati F, Radke TF, Psathaki OE, Hargus G, Kramer J, Einhaus M, Kim JB, Kögler G, Wernet P, Schöler HR, Schlenke P, Zaehres H. 
Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin. Haematologica. 2015 Jan;100(1):32-41

Gunnar Hargus, Marc Ehrlich, Marcos J. Arau´ zo-Bravo, Kathrin Hemmer, Anna-Lena Hallmann, Peter Reinhardt, Kee-Pyo Kim, Kenjiro Adachi, Simeo Santourlidis, Foued Ghanjati, Mareike Fauser, Christiana Ossig, Alexander Storch, Jeong Beom Kim, Jens C. Schwamborn, Jared Sterneckert, Hans R. Scho¨ ler, Tanja Kuhlmann, and Holm Zaehres. 
Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain.Cell reports. 2014 Sep;8(6):1-7


Yang K, Lee JS, Kim J, Lee YB, Shin H, Um SH, Kim JB, Park KI, Lee H, Cho SW.

Polydopamine-mediated surface modification of scaffold materials for human neural stem cell engineering. Biomaterials. 2012 Oct;33(29):6952-64.


Löhle M, Hermann A, Glass H, Kempe A, Schwarz SC, Kim JB, Poulet C, Ravens U, Schwarz J, Schöler HR, Storch A.

Differentiation efficiency of induced pluripotent stem cells depends on the number of reprogramming factors. Stem cells. 2012 2012 Mar;30(3):570-9. doi: 10.1002/stem.1016.

 

Minnerup J, Kim JB, Schmidt A, Diederich K, Bauer H, Schilling M, Strecker JK, Ringelstein EB, Sommer C, Schöler HR, Schabitz WR.

Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke. Stroke. 2011 Jun; 42(6):1757-63.

 

Zhou H, Li W, Zhu S, Joo JY, Do JT, Xiong W, Kim JB, Zhang K, Schöler HR, Ding S.

Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J Biol Chem. 2010 Sep 24; 285(39):29676-80.Epub 2010 Aug 12.

 

Zaehres H, Kim JB, Schöler HR.

Induced pluripotent stem cells. Methods Enzymol. 2010;476:309-25.

 

Zaehres H, Kögler G, Arauzo-Bravo MJ, Bleidissel M, Santourlidis S, Weinhold S, Greber B, Kim JB, Buchheiser A, Liedtke S, Eilken HM, Graffmann N, Zhao X, Meyer J, Reinhardt P, Burr B, Waclawczyk S, Ortmeier C, Uhrberg M, Schöler HR, Cantz T, Wernet P.

Induction of pluripotency in human cord blood unrestricted somatic stem cells. Exp Hematol. 2010 Sep; 38(9):809-18,818.e1-2. Epub 2010 Jun 10.

 

Kim, J. B., Greber, B., Arauzo-Bravo, M. J., Meyer, J., Park, K. I., Zaehres, H.,  Schöler HR.

Direct Reprogramming of Human Neural Stem Cells by Oct4. Nature 2009;461(7264):649-653.



Kim J. B., Zaehres, H., Arauzo-Bravo, M. J., Schöler HR.

Gerneration of induced pluripotent stem cells from neural stem cells. Nature Protocols 2009;4(10):1464-1470.

 

Ko, K., Tapia, N., Wu, G., Kim, J. B., Arauzo-Bravo, M. J., Sasse, P., Schöler HR.

Induction of Pluripotency in Adult Unipotent Germline Stem Cells. Cell Stem Cells 2009;5:87-96.

 

Kim J. B., Sebastiano, V., Wu, G., Arauzo-Bravo, M. J., Sasse, P., Gentile, L., Zaehres, H.,and Schöler HR.

Oct-4 Induced Pluripotency in Adult Neural Stem Cells. Cell 2009;136:411-419.

 

Kim, J. B., Zaehres, H., Wu, G., Schöler HR.

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008;454:646-650.

 

Graumann J, Hubner NC, Kim J. B., Schöler H, Mann M.

Stable isotope labeling by amino acids in cell  culture (SILAC) and proteome quantitation of mouse embryonic  stem cells to a depth of 5,111 proteins. Mol Cell Proteomics 2008;7(4):672-683.